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Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina BJMBR
Iturry-Yamamoto,G.R.; Moriguchi,E.H.; Zago,A.C.; Alho,C.S.; Zago,A.J..
The 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene consists of the substitution of a guanine base by a thymine at the 894th nucleotide of the gene. An association of this polymorphism with acute coronary syndromes has been described, only when in combination with other polymorphisms of this gene. The aim of the present study was to search for an association between this polymorphism and unstable angina in a southern Brazilian population. In a case-control study, 156 patients (group 1 (N = 83): unstable angina, group 2 (N = 73): stable angina) were genotyped by PCR and digestion of the product. Univariate analysis demonstrated that the minimal luminal diameter and the degree of stenosis of the culprit lesion differed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide synthase; Gene; Polymorphism; Unstable angina; Coronary.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400005
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Lack of a relationship between serum ferritin levels and coronary atherosclerosis evaluated by coronary arteriography BJMBR
Manfroi,W.C.; Zago,A.J.; Cruz,R.; Oliveira,J.; Kirschnick,L.S.; Ordovás,K.; Candiago,R.H.; Souza,J.; Ribeiro,L.W.; Leitão,C.; Brizolara,M.L..
Many clinical and epidemiological studies have demonstrated the relationship between serum ferritin and ischemic heart disease. In the present study we evaluated the relationship between coronary heart disease (CHD) and serum ferritin levels in patients submitted to coronary arteriography. We evaluated 307 patients (210 (68.7%) males; median age: 60 years) who were submitted to coronary angiography, measurement of serum ferritin and identification of clinical events of ischemic heart disease. Serum ferritin is reported as quartiles. Ninety-six patients (31.27%) had normal coronary angiography (group 1) and 211 (68.73%) had coronary heart disease (group 2). Of the patients with CHD, 61 (28.9%) had serum ferritin levels higher than 194 ng/ml (4th quartile),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ferritin; Coronary heart disease; Atherosclerosis; Risk factors; Coronary arteriography.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300009
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Postangioplasty restenosis: a practical model in the porcine carotid artery BJMBR
Caramori,P.R.A.; Eggers,E.E.; Silva-Filho,A.P.F.; Uchoa,D.M.; Jung,F.; Zago,A.C.; Cerski,C.T.S.; Schwartsmann,G.; Zago,A.J..
Transluminal coronary angioplasty is a routine therapeutic intervention in coronary heart disease. Despite the high rate of primary success, restenosis continues to be its major limitation. Porcine models have been considered to be the most adequate experimental models for studying restenosis. One limitation of porcine models is the need for radiological guidance and the expenses involved. The objective of the present study was to adapt an experimental model of angioplasty in the porcine carotid artery that does not require radiological equipment. Eight animals were used to develop the technique of balloon injury to the common carotid artery by dissection without radiological guidance. This technique was then employed in six other animals. Under...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Arterial injury; Intimal hyperplasia; Restenosis; Percutaneous transluminal coronary angioplasty.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900007
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